The story of the onset of the HIV-AIDS crisis in New York City in the early 1980s, taking an unflinching look at the nation's sexual politics as gay activists and their allies in the medical community fight to expose the truth about the burgeoning epidemic to a city and nation in denial.
This shape-shifting tale of the perils and pleasures of self-reinvention begins at a dinner party, when Tom's (Michael Shannon) co-worker arrives with an intriguing date named Alice (Rachel Weisz). Tom is convinced he knows her, but she refuses to acknowledge their history. And when Alice makes a hasty exit, Tom sets off after her. What follows is an all-night odyssey shared by two people, one needing to change his life, the other questioning how to stop changing.